Investigating how calcium signaling affects small pulmonary arteries
Flow-Activated Calcium Signaling Microdomains in Small Pulmonary Arteries
This study is looking at how certain cells in your lungs help control blood flow and pressure, especially in people with pulmonary hypertension, to find new ways to improve treatments for this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11141301 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms of calcium signaling that regulate the dilation of small pulmonary arteries, which is crucial for maintaining normal blood pressure in the lungs. The team will explore how specific channels in endothelial cells respond to blood flow and how these responses may be impaired in conditions like pulmonary hypertension. By studying the interactions between different proteins involved in this signaling pathway, the researchers aim to uncover new insights that could lead to better treatments for patients with pulmonary hypertension.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary hypertension or those at risk for developing this condition.
Not a fit: Patients with other forms of cardiovascular disease unrelated to pulmonary hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating pulmonary hypertension, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding calcium signaling in vascular health, suggesting that this approach may yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Sonkusare, Swapnil K. — University of Virginia
- Study coordinator: Sonkusare, Swapnil K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.