Investigating how calcium-sensing receptors interact with GABA receptors in breast cells.
Heterodimerization of the Calcium-sensing receptor with the GabaB receptors in the breast.
This study is looking at how certain receptors in breast cells work together to manage calcium and protein release during breastfeeding and in breast cancer, which could help us find new ways to understand and treat breast cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10889200 on NIH RePORTER |
What this research studies
This research explores the interaction between calcium-sensing receptors and GABA receptors in breast epithelial cells. It focuses on how these receptors influence calcium transport and the secretion of specific proteins during lactation and in breast cancer. By examining the signaling pathways involved, the study aims to uncover new insights into the regulation of breast cell functions. Patients may benefit from a better understanding of breast cancer mechanisms and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with breast cancer or those undergoing lactation.
Not a fit: Patients without breast cancer or those not involved in lactation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for breast cancer by targeting specific receptor interactions.
How similar studies have performed: Other research has shown promising results in understanding receptor interactions in cancer biology, suggesting potential for success in this area.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Wysolmerski, John J — Yale University
- Study coordinator: Wysolmerski, John J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.