Investigating how calcium release in brain cells affects learning.
Defining the Circuit, Synaptic, and Molecular Mechanisms Linking Intracellular Ca2+ Release to Learning Using Subcellularly-Targeted Manipulations and Imaging Techniques in Dendrites in Vivo
This study is looking at how calcium in brain cells affects learning and memory, especially when it comes to finding our way around, and the findings could help improve treatments for conditions like Alzheimer's and autism.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10973751 on NIH RePORTER |
What this research studies
This research explores the relationship between calcium release within brain cells and the mechanisms of learning. By using advanced imaging techniques, the study aims to observe how calcium dynamics in dendrites of neurons influence behavior and neural plasticity in live animals. The research focuses on understanding the role of intracellular calcium release in shaping learning experiences, particularly in the context of spatial navigation. Patients may benefit from insights gained about learning processes that could inform treatments for conditions like Alzheimer's disease and autism.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with Alzheimer's disease or autism spectrum disorders.
Not a fit: Patients with conditions unrelated to learning or memory, such as purely physical ailments, may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing learning and memory in patients with neurological conditions.
How similar studies have performed: Previous research has shown promising results in understanding calcium dynamics in neurons, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: O'hare, Justin — University of Colorado Denver
- Study coordinator: O'hare, Justin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.