Investigating how calcium regulation affects hearing loss in cochlear cells.
Calcium Regulation in Cochlear Cells
This study is looking at how changes in calcium levels in tiny hair cells in the ear might cause hearing loss as we age, and it aims to find ways to protect these cells to help older adults keep their hearing longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11058784 on NIH RePORTER |
What this research studies
This research focuses on understanding acquired hearing loss (AHL), particularly in aging individuals, by examining the role of calcium regulation in cochlear hair cells. The study aims to explore how mitochondrial dysfunction and calcium overload contribute to the damage and death of these cells, which are crucial for hearing. By using acoustic stimulation and analyzing the cellular responses, researchers hope to uncover the mechanisms behind AHL and identify potential therapeutic targets. The findings could lead to new strategies for preventing or mitigating hearing loss in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related hearing loss or those at risk of acquired hearing loss.
Not a fit: Patients with congenital hearing loss or those whose hearing loss is unrelated to age or acoustic exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help preserve hearing in aging individuals.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dysfunction in hearing loss, indicating that this approach has potential for success.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Stepanyan, Ruben — Case Western Reserve University
- Study coordinator: Stepanyan, Ruben
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.