Investigating how calcium channels affect Alzheimer's disease
Official title: L-type calcium channels in Alzheimer’s disease pathophysiology
Funded at University of Texas Hlth Science Center · NIH-11160794 · Data updated 2026-11-12
This study is looking at how certain calcium channels in the brain might affect the progression of Alzheimer's disease, and it hopes to find new ways to protect brain cells and improve treatment options for people with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | August 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $563,501 |
| NIH project number | 5R01AG085531-02 |
| Project ID | NIH-11160794 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's disease or those experiencing early symptoms of cognitive decline.
✕Less likely to help
Patients with advanced Alzheimer's disease or those with other forms of dementia may not benefit from this research.
What this research studies
This research explores the role of L-type calcium channels in the development and progression of Alzheimer's disease. It aims to understand how these channels contribute to calcium dysregulation, which is linked to cognitive decline and tau pathology. By using specific animal models, the researchers will evaluate the effects of calcium channel antagonists on cellular dysfunction related to amyloid plaques and neuroinflammation. The study seeks to uncover potential neuroprotective mechanisms that could lead to new therapeutic strategies for Alzheimer's patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect against cognitive decline in Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results with calcium channel antagonists in reducing Alzheimer's pathology, indicating potential for success in this approach.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Hopp, Sarah Christine — University of Texas Hlth Science Center
- Study coordinator: Hopp, Sarah Christine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.