Investigating how calcium affects myelin remodeling during learning
Official title: Does Learning Require Calcium-Dependent Myelin Remodeling?
Funded at Stanford University · NIH-10982236 · Data updated 2026-11-12
This study is looking at how a protective layer around nerves, called myelin, helps our brains learn new things, and it’s especially for people interested in understanding conditions like multiple sclerosis, where this layer can be damaged.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $599,204 |
| NIH project number | 1R01NS134829-01A1 |
| Project ID | NIH-10982236 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting myelin, such as multiple sclerosis, or those interested in understanding learning processes.
✕Less likely to help
Patients with conditions unrelated to myelin or calcium signaling may not benefit from this research.
What this research studies
This research explores the role of myelin, a protective sheath around nerves, in learning processes. It aims to understand how calcium signaling in oligodendrocytes, the cells that produce myelin, influences the remodeling of myelin sheaths during learning activities. By studying these mechanisms in mice, the researchers hope to uncover how myelin dynamics contribute to the brain's ability to adapt and learn new skills. This could lead to new insights into conditions like multiple sclerosis, where myelin is damaged.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for enhancing learning and recovery in patients with myelin-related disorders.
How similar studies have gone: Previous research has shown that myelin is dynamic and plays a role in neural plasticity, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Zuchero, John B — Stanford University
- Study coordinator: Zuchero, John B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.