Investigating how calcium affects heart tissue changes in atrial fibrillation
Official title: Calcium Driven Fibroblast Dysregulation in Human Atrial Profibrotic Remodeling
Funded at University of California at Davis · NIH-11024016 · Data updated 2026-11-12
This study is looking at how problems with calcium in heart cells might make atrial fibrillation worse, and it hopes to find new ways to help improve treatments for people living with this heart rhythm issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $570,537 |
| NIH project number | 1R01HL176651-01 |
| Project ID | NIH-11024016 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with atrial fibrillation, particularly those experiencing early stages of the condition.
✕Less likely to help
Patients with advanced or irreversible atrial fibrillation may not benefit from this research.
What this research studies
This research focuses on understanding the role of calcium in the development of atrial fibrillation (AF), a common heart rhythm disorder. It aims to explore how calcium dysregulation in heart cells, particularly fibroblasts, contributes to the structural changes that make AF worse. By examining these mechanisms, the research seeks to identify new therapeutic strategies that could prevent or reverse the progression of AF. Patients may benefit from insights that lead to improved treatments targeting the underlying causes of their condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively manage or even reverse atrial fibrillation.
How similar studies have gone: Previous research has shown promise in targeting calcium dysregulation as a therapeutic approach in heart conditions, suggesting potential for success in this area.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Grandi, Eleonora — University of California at Davis
- Study coordinator: Grandi, Eleonora
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.