Investigating how calciprotein particles affect blood vessel calcification in kidney disease patients
Official title: Calciprotein Particles and Vascular Calcification in Patients with Chronic Kidney Disease
Funded at Albert Einstein College of Medicine · NIH-11005297 · Data updated 2026-11-12
This study is looking at how tiny particles in the blood, called calciprotein particles, might cause blood vessel hardening in people with chronic kidney disease, and it hopes to find new ways to prevent this problem while keeping bones healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $680,994 |
| NIH project number | 5R01HL172073-02 |
| Project ID | NIH-11005297 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with chronic kidney disease who are experiencing vascular calcification.
✕Less likely to help
Patients without chronic kidney disease or those not experiencing vascular calcification may not benefit from this research.
What this research studies
This research focuses on understanding the role of calciprotein particles (CPPs) in causing vascular calcification in patients with chronic kidney disease (CKD). The study aims to determine how excess CPPs in the blood contribute to the calcification of blood vessels, which is a significant health concern for CKD patients. By examining the effects of these particles on vascular smooth muscle cells and endothelial cells, the research seeks to uncover mechanisms that could lead to new therapies. The findings may help identify ways to prevent vascular calcification while preserving bone health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent vascular calcification in CKD patients, potentially reducing mortality rates.
How similar studies have gone: Previous research has shown promising results in understanding the role of calciprotein particles in vascular health, indicating that this approach has potential for success.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Chen, Wei — Albert Einstein College of Medicine
- Study coordinator: Chen, Wei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.