Investigating how calcineurin affects heart remodeling
Calcineurin compartmentation and regulation of pathological cardiac remodeling
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-10800721
This study is looking at how a protein called calcineurin affects heart problems like thickening and failure, and it aims to find safer ways to target this protein to help improve heart health without the side effects of current medications.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10800721 on ClinicalTrials.gov |
What this research studies
This research focuses on the role of the enzyme calcineurin in the development of heart conditions such as hypertrophy and heart failure. It aims to explore how calcineurin can be targeted to prevent harmful changes in heart structure without the side effects associated with current immunosuppressive drugs. By studying specific pathways and mechanisms in heart cells, the researchers hope to identify new therapeutic strategies that could improve heart function and reduce damage. The approach includes advanced imaging techniques to observe how calcineurin interacts with other proteins in heart cells.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with existing heart conditions, particularly those experiencing cardiac hypertrophy or heart failure.
Not a fit: Patients without any heart conditions or those who are not experiencing cardiac remodeling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively manage or prevent heart failure and related conditions.
How similar studies have performed: Previous research has shown promising results in targeting calcineurin pathways, suggesting potential for success in this novel approach.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAPILOFF, MICHAEL SETH — STANFORD UNIVERSITY
- Study coordinator: KAPILOFF, MICHAEL SETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.