Investigating how breathing problems after a stroke affect thinking skills in older adults with Alzheimer's disease.
Official title: Stroke Disordered Breathing and its Impact on Cognitive Decline in Aging, Alzheimer's Disease and Cerebral Amyloid Angiopathy
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10875715 · Data updated 2026-11-12
This study is looking at how breathing problems after a stroke might affect thinking and memory in older adults, especially those with Alzheimer's or certain brain conditions, to find ways to help improve both breathing and brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 11, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $953,252 |
| NIH project number | 4R01AG069466-02 |
| Project ID | NIH-10875715 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above who have experienced a stroke and may also have Alzheimer's disease or related conditions.
✕Less likely to help
Patients who are younger than 65 or those without a history of stroke or neurodegenerative diseases may not benefit from this research.
What this research studies
This research explores the connection between breathing difficulties that occur after a stroke and cognitive decline in older adults, particularly those with Alzheimer's disease and cerebral amyloid angiopathy. The study aims to understand how these breathing issues impact recovery and cognitive function over time. By using animal models, researchers will investigate the mechanisms behind stroke-induced respiratory dysfunction and its effects on brain health. The ultimate goal is to develop interventions that could improve breathing and, in turn, enhance cognitive outcomes for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and quality of life for older adults recovering from strokes.
How similar studies have gone: While the specific approach of this research is novel, there is emerging evidence that addressing respiratory dysfunction can positively impact recovery in stroke patients.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Li, Jun — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Li, Jun
Related research
Other NIH-funded projects on the same topics.
-
How immune cells in the body versus the brain affect memory loss in aging and Alzheimer's
Researchers are comparing whether immune cells in the blood or immune cells in the brain drive memory loss in older adults and people with Alzheimer's.
-
Addressing Alzheimer’s and related dementias and metal exposure in older adults in Bangladesh
This project looks at how lifetime exposure to metals might influence memory loss and dementia risk in people aged 65 and older in Bangladesh, with the goal of finding early blood biomarkers.
-
Understanding brain fluid spaces in aging and Alzheimer's disease
This project explores how tiny fluid-filled spaces in the brain change as we age and in people with early Alzheimer's disease.
-
Investigating changes in brain fluid spaces related to aging and Alzheimer's disease
This study is looking at special spaces in the brain that help remove waste, to see how they change as we age and in the early stages of Alzheimer's disease, so we can better understand brain health and find early signs of cognitive decline.
-
Investigating how immune responses in the body and brain affect cognitive decline in aging and Alzheimer's disease
This study is looking at how immune cells in the brain and body affect memory and thinking problems that come with aging and Alzheimer's disease, and it’s for older adults who want to understand more about what might help keep their minds sharp.
-
How COVID-19 infection and genes may influence memory and dementia risk
This study looks at how getting COVID-19 and a person’s genes together affect the chance of developing memory problems and Alzheimer’s disease later in life.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.