Investigating how breast cancer spreads from bone lesions to other organs
Mechanistic and therapeutic investigation of secondary metastatic seeding from breast cancer bone lesion
This study is looking at how breast cancer that spreads to the bones can also lead to cancer spreading to other parts of the body, with the hope of finding new ways to stop this from happening and help patients with advanced breast cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10977358 on NIH RePORTER |
What this research studies
This research focuses on understanding how breast cancer that initially spreads to the bones can lead to further metastasis in other organs. It aims to explore the mechanisms behind this secondary spread, particularly how cancer cells in the bones can become more aggressive and contribute to the development of additional tumors. By utilizing advanced genomic analyses and pre-clinical models, the study seeks to uncover the pathways of metastatic seeding from bone lesions, which could ultimately help in preventing the progression of the disease. Patients may benefit from insights gained that could lead to new therapeutic strategies to combat advanced breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with breast cancer who have experienced bone metastases.
Not a fit: Patients with breast cancer who do not have bone metastases may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the spread of breast cancer from bones to other vital organs.
How similar studies have performed: While there has been significant research on primary tumor metastasis, this specific investigation into metastasis-to-metastasis seeding is relatively novel and underexplored.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Zhang, Xiang — Baylor College of Medicine
- Study coordinator: Zhang, Xiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.