Investigating how breast cancer and its treatment affect aging in older women
Official title: Long-Term Trajectories of Accelerated Biological Aging and Functional Decline Associated with Breast Cancer and its Treatment
Funded at Kaiser Foundation Research Institute · NIH-10908645 · Data updated 2026-11-12
This study is looking at how breast cancer and its treatments might affect aging and health over time in older women, so we can better understand the unique challenges faced by breast cancer survivors compared to those who haven't had cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kaiser Foundation Research Institute NIH-funded |
| Lab location | 1 site (Oakland, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $623,178 |
| NIH project number | 5R01CA283839-02 |
| Project ID | NIH-10908645 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older women, particularly those over 65, who have a history of invasive breast cancer.
✕Less likely to help
Patients who are younger than 21 or do not have a history of breast cancer may not benefit from this research.
What this research studies
This research examines the long-term effects of breast cancer and its treatments on biological aging and functional decline in older women. By analyzing data from the Women's Health Initiative, the study aims to understand how cancer and its therapies may accelerate aging processes compared to women without a cancer history. The research will track changes in health and aging over time, focusing on factors like treatment type and intensity. This comprehensive approach will help identify specific health risks faced by breast cancer survivors.
Why it matters
Potential benefit: If successful, this research could lead to improved care strategies for older breast cancer survivors, enhancing their quality of life and longevity.
How similar studies have gone: Previous research has indicated that cancer treatments can lead to accelerated aging, suggesting that this study's approach is grounded in established findings.
Where this research is happening
-
Kaiser Foundation Research Institute
Oakland, United States Active
Researchers
- Principal investigator: Feliciano, Elizabeth Marjorie Cespedes — Kaiser Foundation Research Institute
- Study coordinator: Feliciano, Elizabeth Marjorie Cespedes
Related research
Other NIH-funded projects on the same topics.
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Long-Term Aging and Functional Changes After Breast Cancer and Its Treatments
This study looks at how aging and daily functioning change over time in older women who have had breast cancer and its treatments.
-
Cognitive aging in long-term breast cancer survivors
This research explores how aging affects thinking and memory in people who survived breast cancer many years after treatment, focusing on those 65 and older.
-
Aging, DNA Methylation, and Cardio Risk in Breast Cancer Survivors
A study to help breast cancer survivors understand how aging and DNA changes might raise the chance of heart disease.
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How breast cancer treatment affects biological aging and heart health
This project looks at whether breast cancer treatment speeds up biological aging and how that relates to heart strength and fitness in women getting treatment.
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How breast cancer and its treatment affect long-term aging and physical function
This project looks at whether breast cancer and its treatments lead to faster biological aging and physical decline in older women who survived breast cancer.
-
Understanding memory and thinking changes in older breast cancer survivors
This work looks at how memory and thinking skills change over many years in older breast cancer survivors compared to people who haven't had cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.