Investigating how BRCA2 mislocalization affects cancer treatment
Official title: DNA repair dysfunction in cancer induced by altered BRCA2 localization
Funded at Medical University of South Carolina · NIH-10928209 · Data updated 2026-11-12
This study is looking at how a protein called BRCA2, which helps fix DNA, behaves in cancer cells and how its movement can affect treatment results, with the goal of creating better ways to detect and treat cancer for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | September 12, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $205,848 |
| NIH project number | 5K22CA273681-02 |
| Project ID | NIH-10928209 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with breast cancer or other cancers associated with BRCA2 mutations.
✕Less likely to help
Patients without BRCA2 mutations or those with cancers unrelated to DNA repair dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding the role of BRCA2, a key protein involved in DNA repair, and how its mislocalization in cancer cells can influence treatment outcomes. The study will explore the mechanisms that regulate BRCA2's movement between the nucleus and cytoplasm, particularly in the context of cancer-driving mutations. By examining how these mutations affect BRCA2's function and localization, the research aims to develop new diagnostic tools that could improve cancer detection and treatment strategies for patients. The approach includes detailed molecular studies and potential applications in clinical settings.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and treatment options for patients with certain types of cancer, particularly those with BRCA2-related mutations.
How similar studies have gone: Previous research has shown promising results in targeting BRCA2 mislocalization for therapeutic benefits, indicating that this approach has potential for success.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Jimenez Sainz, Judit — Medical University of South Carolina
- Study coordinator: Jimenez Sainz, Judit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.