Investigating how brain tumors respond to different cancer treatments using tiny devices.
Official title: Using implantable microdevices for deep phenotyping of multiple drug responses in brain tumor patients
Funded at Brigham and Women's Hospital · NIH-10891702 · Data updated 2026-11-12
This study is looking at how well different treatments work for gliomas, a tough type of brain cancer, by using tiny devices during surgery to see how the tumors react, so doctors can create better, personalized treatment plans to help patients live longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $682,907 |
| NIH project number | 5R01CA283905-02 |
| Project ID | NIH-10891702 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with gliomas who are undergoing surgical tumor resection.
✕Less likely to help
Patients with brain tumors who are not undergoing surgery or those with other types of brain cancers may not benefit from this research.
What this research studies
This research focuses on gliomas, a type of aggressive brain cancer, by using implantable microdevices during tumor surgeries to assess how well tumors respond to various treatments. The study aims to identify biomarkers that predict responses to established therapies like Temozolomide and new treatment combinations. By placing these devices in tumors, researchers can gather detailed information on tumor responses to 20 different therapies, helping to tailor treatment strategies for individual patients. The goal is to improve survival outcomes by optimizing treatment plans based on real-time data collected during surgery.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment strategies for brain tumor patients, potentially improving their survival rates.
How similar studies have gone: While the use of implantable microdevices for drug response assessment is a novel approach, similar studies have shown promise in other cancer types, indicating potential for success in this area.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Jonas, Oliver — Brigham and Women's Hospital
- Study coordinator: Jonas, Oliver
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.