Investigating how brain sugar metabolism affects neurological diseases.
Brain Glycogen-Metabolism,Mechanisms, and Therapeutic Potential
This study is looking at how the brain uses sugar and stored energy, and how problems with this process might lead to diseases like Alzheimer's and Lafora disease, with the hope of finding better treatments for people affected by these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11090398 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of glucose and glycogen metabolism in the brain, particularly in relation to neurological diseases like Alzheimer's and Lafora disease. It explores how abnormal glucose metabolism leads to the formation of harmful aggregates in brain cells, which may contribute to disease progression. The study employs advanced techniques to investigate these mechanisms and aims to develop therapeutic strategies to target and eliminate these aggregates. By examining these processes, the research seeks to uncover new insights that could lead to improved treatments for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include adolescents and young adults aged 12-20 who are affected by neurological diseases, particularly those with symptoms related to glucose metabolism issues.
Not a fit: Patients with neurological conditions unrelated to glucose metabolism or those outside the age range of 12-20 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve outcomes for patients with Alzheimer's disease and other neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of glucose metabolism in neurological diseases, suggesting that this approach could lead to significant advancements.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Gentry, Matthew S. — University of Florida
- Study coordinator: Gentry, Matthew S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.