Investigating how brain structure affects memory and perception in older adults
How LC Integrity in Older Adults Mediates Perceptual and Memory Processes
This study is looking at how a tiny part of the brain called the Locus Coeruleus affects memory and how we see things as we get older, and it's for older adults who want to understand more about their brain health and its connection to conditions like Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-11096010 on NIH RePORTER |
What this research studies
This research aims to explore how the integrity of the Locus Coeruleus (LC), a small but crucial part of the brain, influences memory and perception in older adults. By using advanced imaging techniques and behavioral assessments, the study will analyze how variations in LC structure and function relate to cognitive abilities. Participants will undergo psychophysical tests and MRI scans to provide insights into the relationship between LC health and cognitive performance, particularly in the context of age-related disorders like Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those experiencing cognitive changes or at risk for neurodegenerative diseases.
Not a fit: Patients with acute cognitive impairments unrelated to aging or neurodegenerative processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for cognitive decline in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of the Locus Coeruleus in cognitive function, but this specific approach is relatively novel.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Hu, Xiaoping P — University of California Riverside
- Study coordinator: Hu, Xiaoping P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.