Investigating how brain stimulation can improve memory and brain health in dementia.
Deep brain stimulation of the Nucleus Basalis of Meynert: the role of stimulation parameters in neurogenesis and cognitive recovery.
This study is looking at how a special treatment called deep brain stimulation can help improve thinking and memory in people with dementia by encouraging the growth of new brain cells, and it will also check for any effects on sleep and stress.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project ID | NIH-10551858 on NIH RePORTER |
What this research studies
This research explores the effects of deep brain stimulation on the Nucleus Basalis of Meynert, a brain region crucial for cognitive function, in the context of dementia. By applying electrical stimulation, the study aims to promote neurogenesis, which is the growth of new neurons, and assess its impact on cognitive recovery. The research will involve experiments on both demented and control rats to evaluate improvements in cognitive abilities and monitor any potential side effects on sleep and stress levels. The findings could lead to new therapeutic strategies for treating dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or other forms of dementia.
Not a fit: Patients with non-dementia related cognitive impairments or those without a diagnosis of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance cognitive function and slow the progression of dementia.
How similar studies have performed: Previous studies have shown promising results with deep brain stimulation in other brain regions, suggesting potential for success in this novel application.
Where this research is happening
Shreveport, United States
- Louisiana State Univ Hsc Shreveport — Shreveport, United States (Active)
Researchers
- Principal investigator: Kumbhare, Deepak — Louisiana State Univ Hsc Shreveport
- Study coordinator: Kumbhare, Deepak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.