Investigating how brain stimulation affects memory in mice with epilepsy
Official title: Theta Phase-Locked Stimulation of Entorhinal-Hippocampal Inputs in Healthy and Epileptic Mice
Funded at Icahn School of Medicine at Mount Sinai · NIH-11075764 · Data updated 2026-11-12
This study is looking at how brain activity affects memory in both healthy mice and those with epilepsy, using a special technique to see how changing brain signals can help us understand memory problems related to epilepsy.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $47,374 |
| NIH project number | 5F31NS134301-02 |
| Project ID | NIH-11075764 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with epilepsy who experience cognitive deficits, particularly those with temporal lobe epilepsy.
✕Less likely to help
Patients without epilepsy or those whose cognitive impairments are unrelated to epilepsy may not benefit from this research.
What this research studies
This research explores the relationship between brain activity and memory performance in both healthy and epileptic mice. By using a novel optogenetic system, the study aims to manipulate the timing of neural inputs during specific brain oscillations to understand their impact on cognitive function. The approach involves precise stimulation of brain regions that are crucial for memory, allowing researchers to observe changes in behavior and memory performance. This could provide insights into how disruptions in brain synchrony contribute to cognitive deficits associated with epilepsy.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving memory and cognitive function in patients with epilepsy.
How similar studies have gone: While the approach of manipulating brain synchrony is innovative, similar studies have shown promise in understanding cognitive functions in animal models.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Philipsberg, Paul Andrew — Icahn School of Medicine at Mount Sinai
- Study coordinator: Philipsberg, Paul Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.