Investigating how brain signals control energy and glucose balance
Perineuronal Nets in the VMH Regulating Energy and Glucose Balance
['FUNDING_R21'] · TUFTS UNIVERSITY BOSTON · NIH-11056180
This study is looking at how a brain protein called BDNF affects hunger and how our bodies use sugar, which could help us understand obesity and related health issues better, so people can learn how their own BDNF levels might influence their weight and blood sugar.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY BOSTON (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11056180 on ClinicalTrials.gov |
What this research studies
This research explores the role of brain-derived neurotrophic factor (BDNF) in regulating energy and glucose levels in the body. It focuses on how changes in BDNF signaling can affect appetite and metabolism, particularly in the ventromedial hypothalamus (VMH), a critical area of the brain for these functions. By studying mice with altered BDNF levels, the research aims to understand the mechanisms behind obesity and metabolic disorders, which could lead to new treatment strategies. Patients may benefit from insights into how their own BDNF levels affect their weight and glucose regulation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include adults with obesity or metabolic disturbances, particularly those with genetic variations affecting BDNF signaling.
Not a fit: Patients who do not have metabolic disorders or obesity may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for obesity and metabolic disorders by targeting BDNF signaling pathways.
How similar studies have performed: Previous research has shown promising results in understanding the role of BDNF in metabolism, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS UNIVERSITY BOSTON — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIOS, MARIBEL — TUFTS UNIVERSITY BOSTON
- Study coordinator: RIOS, MARIBEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.