Investigating how brain signals are modulated during behavior.
Official title: Multiplex interrogation of neuromodulatory signaling in behaving animals with enhanced depth and resolution
Funded at Max Planck Florida Corporation · NIH-10900670 · Data updated 2026-11-12
This study is looking at how brain cells communicate and change when we experience different things, using special tools to see how important chemicals like serotonin and dopamine are released during activities, which could help us understand brain function better and find new ways to treat brain disorders.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Max Planck Florida Corporation NIH-funded |
| Lab location | 1 site (Jupiter, UNITED STATES) |
| Project start | May 1, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $883,967 |
| NIH project number | 5U01NS120820-05 |
| Project ID | NIH-10900670 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with neurological or psychiatric conditions that involve dysregulation of neuromodulators.
✕Less likely to help
Patients with purely structural brain disorders or those not affected by neuromodulatory systems may not benefit from this research.
What this research studies
This research focuses on understanding the complex networks of neurons in the mammalian brain and how they adapt to environmental changes. By using advanced imaging techniques, the study aims to observe the timing and locations of neuromodulator releases, such as serotonin and dopamine, during behavioral activities. The researchers are developing genetically encoded sensors to visualize these processes at a high resolution, which could lead to new insights into brain function and potential therapeutic strategies for neurological disorders.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to neuromodulation, such as addiction and mood disorders.
How similar studies have gone: Previous research has shown success in using similar imaging techniques to study neuromodulator release, indicating a promising avenue for further exploration.
Where this research is happening
-
Max Planck Florida Corporation
Jupiter, United States Active
Researchers
- Principal investigator: Tian, Lin — Max Planck Florida Corporation
- Study coordinator: Tian, Lin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.