Investigating how brain proteins are transported to the blood in Alzheimer's disease
Extracellular vesicle transport of brain-derived proteins to the blood in Alzheimer disease
This study is looking at tiny particles in the blood that might carry important clues about Alzheimer's disease from the brain, helping us find better ways to understand and diagnose the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10875737 on NIH RePORTER |
What this research studies
This research explores the role of extracellular vesicles (EVs) in the transport of proteins related to Alzheimer's disease from the brain to the bloodstream. By using advanced techniques, the study aims to identify specific markers on these vesicles that are associated with Alzheimer's pathology. The researchers will also develop methods to isolate and quantify these brain-derived EVs in blood samples, which could lead to better understanding and diagnosis of Alzheimer's disease. This approach may help in identifying biomarkers that could indicate the presence or progression of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools for Alzheimer's disease, enabling earlier detection and better management of the condition.
How similar studies have performed: Previous research has shown promise in using extracellular vesicles as biomarkers for neurodegenerative diseases, indicating that this approach may yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Shi, Min — University of Washington
- Study coordinator: Shi, Min
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.