Investigating how brain processes affect mental health disorders like autism
Presynaptic Homeostatic Plasticity and Mental Health
This study is looking at how the brain keeps itself balanced and healthy, especially in people with autism and intellectual disabilities, to find new ways to help manage these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11045912 on NIH RePORTER |
What this research studies
This research explores the concept of homeostatic plasticity, which refers to the brain's ability to stabilize its functions despite genetic or environmental challenges. By examining how this process relates to mental health disorders such as autism and intellectual disability, the study aims to uncover the molecular mechanisms involved. The research will analyze neurotransmitter release regulation in the brain, focusing on how it maintains a balance between excitatory and inhibitory signals, which is crucial for mental health. Patients may benefit from insights that could lead to new therapeutic strategies for managing these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or intellectual disabilities, particularly those aged 21 and older.
Not a fit: Patients with mental health disorders not related to autism or intellectual disabilities may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve mental health outcomes for individuals with autism and related disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of homeostatic plasticity in mental health, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Davis, Graeme W — University of California, San Francisco
- Study coordinator: Davis, Graeme W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.