Investigating how brain metabolism is affected in Alzheimer's disease
Hypothalamic and metabolic dysfunction in Alzheimer's disease
This study is looking at how problems in a part of the brain called the hypothalamus, which helps control weight and metabolism, might be affected by Alzheimer's disease, especially due to a buildup of certain proteins, to better understand how these changes could impact the disease's progression and improve care for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11000259 on NIH RePORTER |
What this research studies
This research explores the relationship between hypothalamic dysfunction and metabolic changes in Alzheimer's disease. It aims to understand how the accumulation of amyloid-beta peptides in the brain may disrupt metabolic regulation, particularly in the hypothalamus, which controls body weight and metabolism. By examining these early changes, the research seeks to identify potential mechanisms that contribute to the progression of Alzheimer's disease. The approach combines laboratory studies with clinical insights to bridge the gap between basic science and patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals at risk for Alzheimer's disease, particularly those showing early signs of cognitive decline or metabolic issues.
Not a fit: Patients with advanced Alzheimer's disease or those with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or slowing the progression of Alzheimer's disease by targeting metabolic dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding the role of metabolic dysfunction in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Ishii, Makoto — Ut Southwestern Medical Center
- Study coordinator: Ishii, Makoto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.