Investigating how brain injuries cause inflammation in other organs.
Role of ASC in TBI-Mediated Systemic Inflammation.
This study is looking at how a traumatic brain injury can cause inflammation in other parts of the body and is testing if blocking certain proteins released from the injured brain can help protect those organs from further damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10755728 on NIH RePORTER |
What this research studies
This research focuses on understanding the effects of traumatic brain injury (TBI) on inflammation in the body. It examines how certain proteins released from damaged brain tissue can trigger inflammatory responses in other organs, potentially leading to further damage. The study will analyze the composition of these proteins and their role in causing tissue injury. By using monoclonal antibodies to neutralize specific proteins, the research aims to find ways to reduce organ damage after TBI.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a traumatic brain injury.
Not a fit: Patients with non-traumatic brain injuries or those without any history of brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that minimize organ damage following traumatic brain injuries.
How similar studies have performed: Previous research has shown that targeting inflammatory responses can improve outcomes in similar conditions, suggesting potential for success in this approach.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Keane, Robert W — University of Miami School of Medicine
- Study coordinator: Keane, Robert W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.