Investigating how brain injuries affect attention and thinking in older adults

Who could benefit from this research

What this research studies

This research focuses on the effects of traumatic brain injury (TBI) on cognitive functions, particularly sustained attention and executive function, in older adults aged 65 and above. It aims to explore the role of the cholinergic system, specifically the α7 nicotinic receptors, in modulating cognitive impairments associated with TBI and aging. The study will assess cognitive-behavioral dimensions and evaluate the potential benefits of a novel therapeutic agent, NS 1738, administered over different time frames. By understanding these mechanisms, the research seeks to identify new treatment strategies that could improve cognitive outcomes for older adults affected by TBI.

Why it matters

Where this research is happening

• University of Pittsburgh at Pittsburgh
  Pittsburgh, United States Active

Researchers

• Principal investigator: Bondi, Corina Oana — University of Pittsburgh at Pittsburgh
• Study coordinator: Bondi, Corina Oana

Related research

Other NIH-funded projects on the same topics.

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• Investigating how aging and traumatic brain injury affect attention and executive function.

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  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11128984

• How traumatic brain injuries affect aging and balance in older adults

  This study is looking at how brain injuries from earlier in life might affect your balance and thinking skills as you get older, even if you feel like you've fully recovered, and it's for people who have had a traumatic brain injury and want to understand how it could impact their health in the future.

  NIH research Veterans Health Administration · Gainesville, United States · NIH-10869965

• Investigating how brain injuries affect attention and thinking in older adults

  This study is looking at how a traumatic brain injury can affect thinking skills in older adults and whether a new treatment might help improve those skills and overall quality of life.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10837732

• AI-enhanced virtual reality tool to support remote emergency brain surgery training in Tanzania

  A new AI-powered virtual reality tool helps non-experts in low-resource areas get real-time remote guidance for emergency traumatic brain injury surgery.

  NIH research Duke University · Durham, United States · NIH-11625286

• How head injury affects the heart and blood vessels

  This project aims to find out whether traumatic brain injuries make people more likely to develop hardened arteries and heart problems, especially among veterans.

  NIH research Veterans Health Administration · Ann Arbor, United States · NIH-11520843

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.