Investigating how brain injuries affect attention and thinking in older adults
Traumatic brain injury and aging: targeting the cholinergic system for deficits in sustained attention and executive function
This study is looking at how traumatic brain injury affects thinking skills in older adults, especially focusing on attention and decision-making, and it will test a new treatment to see if it can help improve these skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10984890 on NIH RePORTER |
What this research studies
This research focuses on the effects of traumatic brain injury (TBI) on cognitive functions, particularly sustained attention and executive function, in older adults aged 65 and above. It aims to explore the role of the cholinergic system, specifically the α7 nicotinic receptors, in modulating cognitive impairments associated with TBI and aging. The study will assess cognitive-behavioral dimensions and evaluate the potential benefits of a novel therapeutic agent, NS 1738, administered over different time frames. By understanding these mechanisms, the research seeks to identify new treatment strategies that could improve cognitive outcomes for older adults affected by TBI.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who have suffered a traumatic brain injury.
Not a fit: Patients who are younger than 65 years or those without a history of traumatic brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive function and quality of life for older adults who have experienced traumatic brain injuries.
How similar studies have performed: Previous research has shown promise in targeting the cholinergic system for cognitive impairments, suggesting that this approach may yield beneficial results.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Bondi, Corina Oana — University of Pittsburgh at Pittsburgh
- Study coordinator: Bondi, Corina Oana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.