Investigating how brain imaging can help improve memory outcomes for epilepsy surgery
Multimodal imaging of memory in epilepsy from whole brain networks to local neuronal responses: Implications for surgical decision-making
This study is looking at how different types of brain surgery for temporal lobe epilepsy can affect memory, so we can help patients find the best option for them, especially focusing on a newer, less invasive surgery called SLAH.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10990534 on NIH RePORTER |
What this research studies
This research focuses on understanding the impact of different surgical options for patients with temporal lobe epilepsy, particularly how these options affect memory. By using advanced brain imaging techniques, the study aims to identify which patients are most likely to benefit from a minimally invasive surgery called stereotactic laser amygdalohippocampectomy (SLAH) compared to the traditional anterior temporal lobectomy (ATL). The researchers will analyze brain networks and memory functions through various imaging methods and cognitive tasks to better predict memory outcomes after surgery. This approach could lead to more personalized treatment plans for patients with epilepsy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with temporal lobe epilepsy who are considering surgical options for seizure control.
Not a fit: Patients with epilepsy who are not candidates for surgery or those with other types of epilepsy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved surgical decision-making that minimizes memory decline in epilepsy patients.
How similar studies have performed: Previous research has shown promise in using multimodal imaging techniques to assess brain function, indicating potential success for this novel approach.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Mcdonald, Carrie R — University of California, San Diego
- Study coordinator: Mcdonald, Carrie R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.