Investigating how brain hemorrhage affects tissue damage and recovery using MRI.
Official title: Human Intracerebral Hemorrhage: Impact of Hematoma Size, Hemolysis and Iron Overload on Edema and White Matter Survival by MRI
Funded at University of Michigan at Ann Arbor · NIH-11036320 · Data updated 2026-11-12
This study is looking at how bleeding in the brain affects brain tissue over time using special MRI scans, to help us understand recovery and find better treatments for people who have had a brain bleed.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | February 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $351,000 |
| NIH project number | 5R01NS131514-02 |
| Project ID | NIH-11036320 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an intracerebral hemorrhage and are within the acute to chronic recovery phases.
✕Less likely to help
Patients who have not experienced an intracerebral hemorrhage or those with chronic neurological conditions unrelated to ICH may not benefit from this research.
What this research studies
This research focuses on understanding the impact of intracerebral hemorrhage (ICH) on brain tissue by using advanced MRI techniques. It aims to track changes in brain tissue over time, particularly looking at how the size of the hemorrhage and the presence of iron affect swelling and the survival of white matter. By analyzing MRI markers from the acute phase to chronic recovery, the study seeks to provide insights into the natural progression of ICH and identify potential indicators of recovery. This could help in developing better treatment strategies for patients suffering from ICH.
Why it matters
Potential benefit: If successful, this research could lead to improved prognostic tools and treatment options for patients with intracerebral hemorrhage.
How similar studies have gone: Previous studies using MRI to evaluate brain hemorrhage have shown promising results, indicating that this approach could yield valuable insights into patient outcomes.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Chaudhary, Neeraj — University of Michigan at Ann Arbor
- Study coordinator: Chaudhary, Neeraj
Related research
Other NIH-funded projects on the same topics.
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Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.
-
Statin use after lobar intracerebral hemorrhage
This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.
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Statin use after lobar brain hemorrhage
This trial compares stopping versus continuing statin medicine in people who had a lobar brain bleed to learn effects on repeat bleeding and future heart or stroke events.
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Blocking red blood cell death after brain hemorrhage
A study at Yale is exploring whether stopping a specific kind of red blood cell death after a brain hemorrhage could improve recovery.
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Targeting HDAC3 to reduce brain damage after a brain bleed
This project will test whether blocking a protein called HDAC3 can reduce inflammation and improve recovery after an intracerebral hemorrhage (brain bleed).
-
Silent brain injuries after brain bleed may predict dementia risk
A study using MRI and cognitive tests to see if hidden brain injuries after spontaneous intracerebral hemorrhage help forecast later cognitive decline.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.