Investigating how brain function stability is affected in Jordan's Syndrome
Official title: Homeostatic plasticity in mouse models of Jordan's Syndrome
Funded at University of California, San Francisco · NIH-11134580 · Data updated 2026-11-12
This study is looking at how the brain keeps itself balanced and how this relates to Jordan's Syndrome, a serious condition that affects development, using mice to find ways to help improve treatments for people with this syndrome and similar issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 15, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $559,875 |
| NIH project number | 5R01HD114658-02 |
| Project ID | NIH-11134580 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Jordan's Syndrome or related neurodevelopmental disorders.
✕Less likely to help
Patients with neurodevelopmental disorders not related to Jordan's Syndrome may not benefit from this research.
What this research studies
This research explores the concept of homeostatic plasticity, which refers to the brain's ability to stabilize its functions despite changes. It focuses on understanding how this process is linked to Jordan's Syndrome, a severe neurodevelopmental disorder. Using mouse models, the researchers will examine the molecular mechanisms that may contribute to the disorder and how they can be manipulated for potential therapies. The goal is to uncover new insights that could lead to improved treatments for individuals affected by Jordan's Syndrome and similar conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing Jordan's Syndrome and potentially other neurodevelopmental disorders.
How similar studies have gone: While the specific approach to studying homeostatic plasticity in Jordan's Syndrome is novel, related research has shown promise in understanding neurodevelopmental disorders.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Davis, Graeme W — University of California, San Francisco
- Study coordinator: Davis, Graeme W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.