Investigating how brain function related to emotions is affected after cardiac arrest
Sexually Dimorphic Amygdala Dysfunction in a Mouse Model of Global Cerebral Ischemia
This study is looking at how a lack of blood flow to the brain after a heart attack affects the amygdala, the part of the brain that helps us process emotions, especially fear, and it's aimed at understanding these changes to help improve treatments for people dealing with emotional and memory problems after such events.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10931613 on NIH RePORTER |
What this research studies
This research explores the impact of global cerebral ischemia (GCI), a condition that can occur after cardiac arrest, on the amygdala, which is crucial for emotional processing. Using a mouse model, the study examines how GCI affects amygdala function, particularly focusing on learning and memory related to fear responses. The researchers employ advanced techniques to assess changes in brain circuits and identify specific impairments in emotional learning, especially in male mice. The goal is to uncover mechanisms behind these dysfunctions to inform future therapies for cognitive and emotional issues following cardiac arrest.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have survived cardiac arrest and may be experiencing cognitive or emotional difficulties.
Not a fit: Patients who have not experienced cardiac arrest or those with unrelated cognitive or emotional disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies aimed at improving emotional and cognitive outcomes for patients who have experienced cardiac arrest.
How similar studies have performed: While this specific approach to studying amygdala dysfunction after GCI is novel, related research has shown success in understanding cognitive impairments following cardiac events.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Vigil, Jose Jacob — University of Colorado Denver
- Study coordinator: Vigil, Jose Jacob
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.