Investigating how brain fluid clearance affects protein buildup after a traumatic brain injury
Brain fluid clearance and misfolded protein dynamics following traumatic brain injury
This study is looking at how well the brain cleans out waste and toxins after a traumatic brain injury, and how this might affect recovery and the risk of developing Alzheimer's later on, so it's for anyone interested in understanding the long-term effects of brain injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10933475 on NIH RePORTER |
What this research studies
This research examines the role of cerebrospinal and interstitial fluid systems in clearing waste and toxins from the brain following a traumatic brain injury (TBI). Using advanced neuroimaging techniques, the study aims to measure how effectively the brain clears these substances and how this relates to cognitive recovery and the risk of developing Alzheimer's Disease later on. The researchers will also track the dynamics of amyloid-β, a protein associated with Alzheimer's, to understand its relationship with brain fluid clearance over time. By identifying these mechanisms, the study seeks to provide insights into the long-term effects of TBI on brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have recently experienced a traumatic brain injury.
Not a fit: Patients who have not experienced a traumatic brain injury or those with pre-existing severe cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for patients recovering from traumatic brain injuries and at risk for Alzheimer's Disease.
How similar studies have performed: Previous research has indicated that monitoring brain fluid dynamics and amyloid-β levels can provide valuable insights into brain health, suggesting that this approach may yield significant findings.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Butler, Tracy a. — Weill Medical Coll of Cornell Univ
- Study coordinator: Butler, Tracy a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.