Investigating how brain factors contribute to depression in people with HIV
Neurotrophic Factor Signaling in the Pathogenesis of HIV-associated Depression: Cohort and Mechanistic Studies
['FUNDING_R21'] · UNIVERSITY OF MINNESOTA · NIH-10489370
This study is looking at how a protein called BDNF might affect depression and thinking skills in people living with HIV, using samples from their spinal fluid to find out more about this connection and hopefully improve treatment options.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-10489370 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between brain-derived neurotrophic factor (BDNF) signaling and depression in individuals living with HIV. By analyzing cerebrospinal fluid samples from HIV patients, the study aims to understand how BDNF pathways may influence depression and cognitive function. The researchers will utilize advanced proteomics techniques and machine learning to identify patterns and validate their findings over time. This approach seeks to uncover the biological mechanisms linking HIV and depression, potentially leading to improved treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with HIV who are experiencing symptoms of depression.
Not a fit: Patients who do not have HIV or those without depressive symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for depression in HIV-positive patients.
How similar studies have performed: Previous research has indicated the importance of neurotrophic factors in depression, suggesting that this approach could yield valuable insights, although the specific focus on HIV-associated depression is relatively novel.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LOFGREN, SARAH — UNIVERSITY OF MINNESOTA
- Study coordinator: LOFGREN, SARAH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.