Investigating how brain connections affect alcohol-related cognitive problems in mice
Official title: Role of Prefrontal Cortical Projections to the Midbrain in Alcohol-Induced Cognitive Deficits in Mice
Funded at Vanderbilt University · NIH-10891430 · Data updated 2026-11-12
This study is looking at how alcohol use disorder affects thinking and memory by examining certain brain areas in mice, which could help us find better ways to support people dealing with this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $37,164 |
| NIH project number | 5F30AA031190-02 |
| Project ID | NIH-10891430 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of alcohol use disorder or those experiencing cognitive deficits related to alcohol consumption.
✕Less likely to help
Patients who do not consume alcohol or have no cognitive impairments related to alcohol use may not benefit from this research.
What this research studies
This research explores the impact of alcohol use disorder (AUD) on cognitive functions by examining specific brain pathways in mice. The study focuses on the medial prefrontal cortex and its connections to the midbrain, which are believed to play a crucial role in cognitive deficits associated with alcohol consumption. Using advanced techniques like single-cell calcium imaging and behavioral assessments, the researchers aim to uncover how these neural circuits are affected by alcohol and how they contribute to cognitive impairments. The findings could lead to better understanding and potential treatments for individuals struggling with AUD.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the cognitive impairments caused by alcohol use disorder, potentially informing better treatment strategies.
How similar studies have gone: Previous research has shown promising results in understanding the neural mechanisms of alcohol-related cognitive deficits, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Kandov, Evelyn — Vanderbilt University
- Study coordinator: Kandov, Evelyn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.