Investigating how brain circuits filter sensory information
Official title: Layer-specific manipulation to test feedforward/feedback cortical circuitry
Funded at Massachusetts Institute of Technology · NIH-10992115 · Data updated 2026-11-12
This study is looking at how the brain handles sensory information, which is especially important for understanding conditions like autism, by examining brain activity in monkeys to see how different brain rhythms work together to manage what we sense from the world around us.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | February 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $246,666 |
| NIH project number | 5R01MH131715-03 |
| Project ID | NIH-10992115 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for potential benefit from this research include individuals diagnosed with autism spectrum disorder or related sensory processing issues.
✕Less likely to help
Patients with conditions unrelated to sensory processing or those who do not have autism spectrum disorder may not benefit from this research.
What this research studies
This research explores how the brain's cortex manages sensory information, particularly focusing on the balance between filtering too much or too little input, which may contribute to disorders like autism. By studying brain rhythms, specifically alpha/beta and gamma oscillations, the research aims to understand how these rhythms interact to control sensory processing. Using advanced techniques, including a new closed-loop system and high-density electrodes, the study will manipulate and measure brain activity in monkeys to test its hypotheses about cortical circuitry. The findings could provide insights into the underlying mechanisms of sensory processing disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for individuals with autism and related sensory processing disorders.
How similar studies have gone: Previous research has shown promising results in understanding brain oscillations and their role in sensory processing, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts Institute of Technology
Cambridge, United States Active
Researchers
- Principal investigator: Miller, Earl K — Massachusetts Institute of Technology
- Study coordinator: Miller, Earl K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.