Investigating how brain chemical changes affect mood disorders
Molecular studies of neural histone monoaminylation in normal and aberrant brain plasticity
This study is looking at how stress affects brain chemistry and mood, especially in people with depression, to find out how these changes happen and how they might be treated with antidepressants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11039983 on NIH RePORTER |
What this research studies
This research explores the role of monoaminergic systems in the brain, which are crucial for regulating mood and are linked to disorders like major depressive disorder (MDD). It examines how chronic stress alters gene expression and affects brain function, particularly focusing on a new type of chemical modification of histone proteins that influences gene activity. By studying these mechanisms in preclinical models, the research aims to uncover how stress impacts mood and how these changes can be addressed with antidepressant treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing mood-related disorders, particularly those influenced by stress.
Not a fit: Patients who do not have mood disorders or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for mood disorders by targeting the underlying biological mechanisms affected by stress.
How similar studies have performed: Previous research has shown promising results in understanding the role of monoaminergic systems in mood disorders, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Maze, Ian S. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Maze, Ian S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.