Investigating how brain cells respond to inflammation
How do CNS fibroblasts regulate the response to neuroinflammation?
This study is looking at how certain cells in the brain, called fibroblasts, react during inflammation, like what happens in multiple sclerosis or after a stroke, to see if they help or hurt the healing process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10996119 on NIH RePORTER |
What this research studies
This research explores the role of fibroblasts in the central nervous system (CNS) during neuroinflammation, which can occur in conditions like multiple sclerosis and stroke. By using a mouse model, the researchers aim to understand how fibrotic scars form in response to inflammation and whether these scars help or hinder recovery. The study involves isolating and culturing CNS fibroblasts to analyze their behavior and the production of collagen, which is crucial for tissue repair. The findings could provide insights into the mechanisms of recovery after neuroinflammatory events.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neuroinflammatory conditions such as multiple sclerosis or those who have experienced a stroke.
Not a fit: Patients with non-neuroinflammatory conditions or those not experiencing CNS-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving recovery from neuroinflammatory diseases.
How similar studies have performed: Other research has shown promising results in understanding the role of fibrosis in various organs, but the specific focus on CNS fibrosis in neuroinflammation is relatively novel.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Daneman, Richard — University of California, San Diego
- Study coordinator: Daneman, Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.