Investigating how brain cells interact in Alzheimer's disease
Core B - Animal Vascular-Metabolic-Neural Network Core
This study is looking at how special brain cells called astrocytes help support brain health in people with Alzheimer's disease, and it aims to find new ways to improve their function to benefit patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10897073 on NIH RePORTER |
What this research studies
This research focuses on understanding the roles of astrocytes, a type of brain cell, in Alzheimer's disease and related dementias. By using advanced imaging and electrophysiology techniques, the study aims to explore how these cells support neurons and regulate blood flow in the brain. The research will involve small animal surgeries and various experimental methods to gather data on brain function and metabolism. The findings could lead to new insights into how to target astrocyte reactivity to improve brain health in Alzheimer's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other types of dementia not related to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving brain function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting astrocyte functions in Alzheimer's models, indicating potential for success in this approach.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Sompol, Pradoldej — University of Kentucky
- Study coordinator: Sompol, Pradoldej
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.