Investigating how brain cells develop and function in Alzheimer's disease
High Throughput Clonal Analyses of Gliogenesis in Neocortical and Paleocortical areas of the Mouse Brain
This study is looking at how certain brain cells that help support neurons develop, especially in relation to Alzheimer's disease, using special techniques on mice to better understand what goes wrong in the brain with this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project ID | NIH-10536298 on NIH RePORTER |
What this research studies
This research focuses on understanding the development of glial cells, which support neurons in the brain, particularly in the context of Alzheimer's disease. Using advanced techniques, researchers will trace the lineage of neural stem cells to see how they produce glial cells in the neocortex and paleocortex of mice. By employing genetically modified mice and sophisticated imaging methods, the study aims to clarify the processes involved in gliogenesis and how these processes may be disrupted in neurological diseases. This knowledge could lead to new insights into brain function and potential therapeutic targets for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are at risk for or diagnosed with Alzheimer's disease.
Not a fit: Patients with neurological conditions other than Alzheimer's disease may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of Alzheimer's disease and lead to improved treatments or preventive strategies.
How similar studies have performed: While the approach of using clonal lineage analysis is relatively novel, similar studies have shown promise in understanding neural development and diseases.
Where this research is happening
Raleigh, United States
- North Carolina State University Raleigh — Raleigh, United States (Active)
Researchers
- Principal investigator: Ghashghaei, Hooman Troy — North Carolina State University Raleigh
- Study coordinator: Ghashghaei, Hooman Troy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.