Investigating how brain cells contribute to Alzheimer's disease and related conditions
Brain Cholesterol Biosynthesis in Health and Neurological Disease
This study is looking at how certain brain cells called astrocytes might affect conditions like Alzheimer's and other issues that can lead to memory problems, with the hope of finding new ways to help people with dementia.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10574830 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of astrocytes, a type of brain cell, in neurological diseases like Alzheimer's and vascular contributions to cognitive impairment. By studying specific genetic mutations in model organisms and primary cell cultures, the research aims to uncover how astrocyte dysfunction may lead to cerebrovascular diseases and cognitive decline. The approach involves detailed analysis of brain cell interactions and their impact on vascular health, which could provide insights into new therapeutic strategies for patients with dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of Alzheimer's disease or related cognitive impairments.
Not a fit: Patients with non-neurological conditions or those under 21 years old may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and quality of life for patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of astrocytes in neurological diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Louvi, Angeliki — Yale University
- Study coordinator: Louvi, Angeliki
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.