Investigating how brain cells communicate through tiny particles in the blood.
Surface Signatures of Neuronal and Glial Extracellular Vesicles
This study is looking at tiny particles released by brain cells that help them communicate, and it's for anyone interested in how these particles can be collected from blood to better understand their role in both healthy and sick brains.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Meso Scale Diagnostics, LLC NIH-funded |
| Lab location | 1 site (Rockville, United States) |
| Project ID | NIH-10460520 on NIH RePORTER |
What this research studies
This research focuses on understanding how extracellular vesicles (EVs), which are small particles secreted by brain cells, play a role in communication within the central nervous system. The team aims to develop a method to capture specific types of EVs from blood samples based on unique surface markers that indicate their origin from particular cell types. By using advanced screening techniques, they will identify these surface signatures and improve the specificity of EV capture, which is crucial for studying their functions in both healthy and diseased brains.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions or those interested in understanding brain health.
Not a fit: Patients with conditions unrelated to brain health or those not providing blood samples may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for neurological diseases by enhancing our understanding of brain cell communication.
How similar studies have performed: Previous research has shown promise in using surface markers for isolating EVs, indicating that this approach could yield valuable insights.
Where this research is happening
Rockville, United States
- Meso Scale Diagnostics, LLC — Rockville, United States (Active)
Researchers
- Principal investigator: Routenberg, David Aaron — Meso Scale Diagnostics, LLC
- Study coordinator: Routenberg, David Aaron
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.