Investigating how brain cells called astrocytes affect motor skills as we age
Official title: Targeting astrocytes to prevent motor decline in aging
Funded at Salk Institute for Biological Studies · NIH-11039619 · Data updated 2026-11-12
This study is looking at how certain brain cells called astrocytes change as we get older and how these changes might affect our movement and thinking skills, with the hope of finding ways to help older adults stay sharp and active.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project start | September 30, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $522,500 |
| NIH project number | 1R21AG091117-01 |
| Project ID | NIH-11039619 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older, particularly those experiencing early signs of cognitive decline or motor difficulties.
✕Less likely to help
Patients who are not experiencing any cognitive or motor decline may not benefit from this research.
What this research studies
This research focuses on understanding the role of astrocytes, a type of brain cell, in the decline of motor skills and cognitive function associated with aging. By examining changes in astrocytes in the cerebellum of both mice and humans, the study aims to identify molecular alterations that contribute to these declines. The researchers will utilize advanced techniques like RNA sequencing to analyze the genetic changes in astrocytes, particularly looking for factors that may influence brain health as we age. This could lead to new insights into how to maintain motor function and cognitive abilities in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing motor decline and improving cognitive health in aging populations.
How similar studies have gone: Previous research has shown promising results in understanding the role of astrocytes in brain health, indicating that this approach may yield valuable insights.
Where this research is happening
-
Salk Institute for Biological Studies
La Jolla, United States Active
Researchers
- Principal investigator: Allen, Nicola J — Salk Institute for Biological Studies
- Study coordinator: Allen, Nicola J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.