Investigating how brain cells affect seizures after traumatic brain injury
Role of hippocampal interneurons in aberrant neurogenesis and epilepsy after traumatic brain injury
This study is looking at how certain brain cells might contribute to seizures after a traumatic brain injury, especially in veterans, and aims to find new ways to help control those seizures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland VA Medical Center NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11109404 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific brain cells, known as interneurons, in the development of seizures following traumatic brain injury (TBI), particularly in veterans. The study examines how these cells interact with newly formed brain cells in the hippocampus, a region critical for memory and learning. By exploring the mechanisms behind post-traumatic epilepsy, the research aims to identify potential new treatments that could improve seizure control for affected individuals. The approach involves detailed cellular analysis and may lead to innovative therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans who have experienced traumatic brain injury and are suffering from post-traumatic epilepsy.
Not a fit: Patients who do not have a history of traumatic brain injury or who do not experience seizures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for veterans suffering from seizures due to traumatic brain injury.
How similar studies have performed: Previous research has shown promise in understanding the cellular mechanisms of epilepsy, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Portland VA Medical Center — Portland, United States (Active)
Researchers
- Principal investigator: Butler, Corwin — Portland VA Medical Center
- Study coordinator: Butler, Corwin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.