Investigating how brain cells affect seizures after traumatic brain injury

Who could benefit from this research

What this research studies

This research focuses on understanding the role of specific brain cells, known as interneurons, in the development of seizures following traumatic brain injury (TBI), particularly in veterans. The study examines how these cells interact with newly formed brain cells in the hippocampus, a region critical for memory and learning. By exploring the mechanisms behind post-traumatic epilepsy, the research aims to identify potential new treatments that could improve seizure control for affected individuals. The approach involves detailed cellular analysis and may lead to innovative therapeutic strategies.

Why it matters

Where this research is happening

• Portland VA Medical Center
  Portland, United States Active

Researchers

• Principal investigator: Butler, Corwin — Portland VA Medical Center
• Study coordinator: Butler, Corwin

Related research

Other NIH-funded projects on the same topics.

• How mild traumatic brain injuries affect brain function and seizures in veterans with epilepsy

  This study is looking at how mild traumatic brain injuries can affect brain function and lead to epilepsy in veterans, and it aims to find new ways to help improve their symptoms and overall quality of life.

  NIH research Veterans Health Administration · Nashville, United States · NIH-10948906

• AI-enhanced virtual reality tool to support remote emergency brain surgery training in Tanzania

  A new AI-powered virtual reality tool helps non-experts in low-resource areas get real-time remote guidance for emergency traumatic brain injury surgery.

  NIH research Duke University · Durham, United States · NIH-11625286

• How head injury affects the heart and blood vessels

  This project aims to find out whether traumatic brain injuries make people more likely to develop hardened arteries and heart problems, especially among veterans.

  NIH research Veterans Health Administration · Ann Arbor, United States · NIH-11520843

• Neural targets for improving function in Veterans with alcohol use disorder and mild brain injury

  This project tests a targeted brain-stimulation approach to help Veterans who have both alcohol use problems and mild traumatic brain injury improve daily functioning.

  NIH research Edward Hines Jr VA Hospital · Hines, United States · NIH-11518051

• How head injuries affect the heart and blood vessels

  This project is looking at whether past traumatic brain injuries cause changes in blood vessels and raise the risk of heart disease for people who have had head injuries.

  NIH research Veterans Health Administration · Ann Arbor, United States · NIH-11516262

• Keeping oxygen in the injured brain after severe head trauma

  This project uses a small brain oxygen monitor to guide ICU care for people with severe traumatic brain injury in hopes of improving recovery.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11474479

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.