Investigating how brain cells affect brain connectivity in infants after injury
Role of interneurons in resting state fMRI connectivity during normal development and after perinatal brain injury
['FUNDING_R01'] · ENDEAVOR HEALTH CLINICAL OPERATIONS · NIH-10914861
This study is looking at how certain brain cells help newborns' brains connect and communicate, especially after injuries, to find early signs of potential learning or behavior challenges, so we can help those babies get the support they need as soon as possible.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ENDEAVOR HEALTH CLINICAL OPERATIONS (nih funded) |
| Locations | 1 site (EVANSTON, UNITED STATES) |
| Trial ID | NIH-10914861 on ClinicalTrials.gov |
What this research studies
This research explores the role of specific brain cells called interneurons in how the brain connects and communicates during normal development and after brain injuries in newborns. By using a non-invasive imaging technique called resting state functional MRI (rsfMRI), the study aims to identify early indicators of cognitive and behavioral issues that may arise from perinatal brain injuries. The goal is to understand the mechanisms behind brain connectivity and to develop objective measures that can predict long-term outcomes for affected infants. This could lead to earlier interventions and better support for children at risk of developmental impairments.
Who could benefit from this research
Good fit: Ideal candidates for this research include newborns who have experienced hypoxic-ischemic brain injuries, as well as healthy infants for comparison.
Not a fit: Patients who are older than 4 weeks or those without any history of brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide early diagnostic tools to identify infants at risk for cognitive and behavioral deficits, allowing for timely interventions.
How similar studies have performed: Other research has shown promise in using rsfMRI to assess brain connectivity in infants, indicating that this approach may yield valuable insights.
Where this research is happening
EVANSTON, UNITED STATES
- ENDEAVOR HEALTH CLINICAL OPERATIONS — EVANSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DROBYSHEVSKY, ALEXANDER — ENDEAVOR HEALTH CLINICAL OPERATIONS
- Study coordinator: DROBYSHEVSKY, ALEXANDER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury