Investigating how brain cells affect brain connectivity in infants after injury
Official title: Role of interneurons in resting state fMRI connectivity during normal development and after perinatal brain injury
Funded at Endeavor Health Clinical Operations · NIH-10914861 · Data updated 2026-11-12
This study is looking at how certain brain cells help newborns' brains connect and communicate, especially after injuries, to find early signs of potential learning or behavior challenges, so we can help those babies get the support they need as soon as possible.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endeavor Health Clinical Operations NIH-funded |
| Lab location | 1 site (Evanston, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $439,758 |
| NIH project number | 5R01NS119251-04 |
| Project ID | NIH-10914861 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include newborns who have experienced hypoxic-ischemic brain injuries, as well as healthy infants for comparison.
✕Less likely to help
Patients who are older than 4 weeks or those without any history of brain injury may not benefit from this research.
What this research studies
This research explores the role of specific brain cells called interneurons in how the brain connects and communicates during normal development and after brain injuries in newborns. By using a non-invasive imaging technique called resting state functional MRI (rsfMRI), the study aims to identify early indicators of cognitive and behavioral issues that may arise from perinatal brain injuries. The goal is to understand the mechanisms behind brain connectivity and to develop objective measures that can predict long-term outcomes for affected infants. This could lead to earlier interventions and better support for children at risk of developmental impairments.
Why it matters
Potential benefit: If successful, this research could provide early diagnostic tools to identify infants at risk for cognitive and behavioral deficits, allowing for timely interventions.
How similar studies have gone: Other research has shown promise in using rsfMRI to assess brain connectivity in infants, indicating that this approach may yield valuable insights.
Where this research is happening
-
Endeavor Health Clinical Operations
Evanston, United States Active
Researchers
- Principal investigator: Drobyshevsky, Alexander — Endeavor Health Clinical Operations
- Study coordinator: Drobyshevsky, Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.