Investigating how brain cell interactions and signaling contribute to changes in Alzheimer's Disease.
Contributions of cell type and exosome signaling to prodromal synaptic and circuit changes in Alzheimer's Disease models
This study is looking at how tiny particles released by brain cells might affect the health of neurons and other brain cells in people with Alzheimer's Disease, using special lab-grown brain cells to better understand these changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10540117 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of different brain cell types and their signaling mechanisms in Alzheimer's Disease (AD). It aims to explore how extracellular vesicles (EVs), which are tiny particles released by cells, can influence the health and function of neurons, astrocytes, and microglia in the context of AD. By using advanced techniques to create human brain cells from induced pluripotent stem cells (iPSCs), the study will analyze the content of EVs and how genetic factors may affect their signaling properties. This could provide insights into the early changes in brain function associated with AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to Alzheimer's Disease or those showing early signs of cognitive decline.
Not a fit: Patients with non-Alzheimer's forms of dementia or cognitive impairment unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new biomarkers for early detection of Alzheimer's Disease and potential therapeutic targets.
How similar studies have performed: Previous research has shown promising results in understanding the role of extracellular vesicles in other neurological diseases, suggesting potential for success in this area as well.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Cline, Hollis T. — Scripps Research Institute, the
- Study coordinator: Cline, Hollis T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.