Investigating how brain blood vessels contribute to inflammation in Alzheimer's Disease
Official title: Cerebrovascular mitochondria as mediators of neuroinflammation in Alzheimer's Disease
Funded at Temple Univ of the Commonwealth · NIH-10895539 · Data updated 2026-11-12
This study is looking at how certain parts of brain cells might be affected by a sticky protein linked to Alzheimer's, and how this could lead to inflammation in the brain; the goal is to find new ways to help improve treatments for people with Alzheimer's.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $111,672 |
| NIH project number | 5K99AG083227-02 |
| Project ID | NIH-10895539 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's Disease or those exhibiting early signs of cognitive decline.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's Disease may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of cerebrovascular mitochondria in the development of neuroinflammation associated with Alzheimer's Disease (AD). It examines how the accumulation of amyloid beta around brain blood vessels can lead to dysfunction in the neurovascular unit, which is crucial for maintaining brain health. By studying the mechanisms of amyloid clearance and the impact of mitochondrial function in endothelial cells, the research aims to uncover new insights into the progression of AD and potential therapeutic targets. Patients may benefit from findings that could lead to improved treatments for managing or preventing neuroinflammation in Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating neuroinflammation in Alzheimer's Disease, potentially slowing disease progression.
How similar studies have gone: Previous research has shown promising results in understanding the role of amyloid beta in neuroinflammation, making this approach a continuation of established findings.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Parodi-Rullan, Rebecca Maria — Temple Univ of the Commonwealth
- Study coordinator: Parodi-Rullan, Rebecca Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.