Investigating how brain blood flow and oxygen levels change in different brain areas
Effects of standard fMRI calibrations on the diverse microvascular blood flow and oxygenation responses in cortical layers
This study is looking at how blood flow and oxygen use in the brain change in different areas as mice age, which could help us create better ways to understand brain activity and improve tools for diagnosing and treating brain conditions in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10917061 on NIH RePORTER |
What this research studies
This research aims to understand how blood flow and oxygen metabolism in the brain vary across different regions and conditions. By using advanced imaging techniques, the study will measure these changes in real-time, focusing on healthy aging in mice. The findings could help develop better models for interpreting brain activity through functional MRI (fMRI), which is crucial for understanding brain function and disorders. Patients may benefit from improved diagnostic tools and treatments based on these insights.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with neurological conditions or those interested in brain health, particularly in the context of aging.
Not a fit: Patients with acute neurological injuries or those not involved in brain health studies may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to enhanced understanding and treatment of brain-related conditions by improving fMRI technology.
How similar studies have performed: Other research has shown promising results in understanding brain function through advanced imaging techniques, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Sencan-Egilmez, Ikbal — Washington University
- Study coordinator: Sencan-Egilmez, Ikbal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.