Investigating how brain blood flow affects dementia
Official title: Brain capillary endothelial cell energetics and neurovascular uncoupling in dementia
Funded at University of Colorado Denver · NIH-11030989 · Data updated 2026-11-12
This study is looking at how changes in the tiny blood vessels in the brain might lead to memory problems and dementia, especially in Alzheimer's, by using special imaging and energy studies, and it will involve both people and mice to find early signs of these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 24, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $2,398,590 |
| NIH project number | 1RF1NS140137-01 |
| Project ID | NIH-11030989 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, particularly those showing early signs of cognitive impairment.
✕Less likely to help
Patients with dementia not related to Alzheimer's disease or those with advanced stages of cognitive decline may not benefit from this research.
What this research studies
This research focuses on understanding how changes in the small blood vessels of the brain contribute to cognitive decline and dementia, particularly in Alzheimer's disease. By using advanced imaging techniques and studying energy metabolism in brain cells, the team aims to uncover the mechanisms behind impaired blood flow and its impact on brain function. The research will involve both patient observations and mouse models to explore the early signs of dementia and how they relate to blood vessel health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating dementia by improving brain blood flow.
How similar studies have gone: Other research has shown promising results in understanding the relationship between brain blood flow and cognitive function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Dabertrand, Fabrice — University of Colorado Denver
- Study coordinator: Dabertrand, Fabrice
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.