Investigating how brain activity influences neuron development and plasticity
Experience-dependent Cellular Plasticity Mechanisms
This study is looking at how brain activity helps brain cells grow and change, using tadpoles to see how visual experiences can help repair the brain after injuries, with the hope of finding better ways to support recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11018643 on NIH RePORTER |
What this research studies
This research explores the mechanisms by which brain activity contributes to the development and adaptability of neurons and neural circuits. By using a model organism, the Xenopus tadpole, the study examines how visual stimuli can induce changes in protein synthesis that are crucial for circuit plasticity. The researchers employ advanced techniques such as proteomics, electrophysiology, and behavioral assays to understand how these processes work in response to brain injuries. The ultimate goal is to uncover ways to enhance recovery and functional outcomes following central nervous system damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced acquired brain injuries and may benefit from enhanced plasticity mechanisms.
Not a fit: Patients with stable neurological conditions that do not involve plasticity-related issues may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting recovery and improving outcomes for patients with brain injuries.
How similar studies have performed: Previous research has shown promising results in understanding circuit plasticity and recovery mechanisms in animal models, indicating potential for success in this area.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Cline, Hollis T. — Scripps Research Institute, the
- Study coordinator: Cline, Hollis T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.