Investigating how brain activity changes and protein buildup contribute to Alzheimer's disease
Official title: The role of neuronal hyperexcitability and proteostasis in Alzheimer's disease
Funded at Winifred Masterson Burke Med Res Inst · NIH-11242554 · Data updated 2026-11-12
This study is looking at how changes in brain activity and protein buildup in a specific area of the brain might lead to Alzheimer's disease, using mice to help us understand what happens early on, which could help us find new ways to prevent or treat the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Winifred Masterson Burke Med Res Inst NIH-funded |
| Lab location | 1 site (White Plains, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,075,563 |
| NIH project number | 7RF1AG087504-02 |
| Project ID | NIH-11242554 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals at risk for Alzheimer's disease, particularly those with early signs of cognitive decline or family history of the condition.
✕Less likely to help
Patients who are already diagnosed with advanced Alzheimer's disease may not benefit from this research.
What this research studies
This research explores the early changes in brain activity and protein accumulation that may lead to Alzheimer's disease. Using a mouse model, the study focuses on the locus coeruleus, a brain region that shows early signs of Alzheimer's pathology, and examines how altered electrical signals and protein management affect disease progression. The goal is to understand the mechanisms behind neuronal hyperexcitability and proteostasis, which could provide insights into the disease's development and potential interventions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting early pathological changes.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown that targeting early pathological changes in Alzheimer's can lead to meaningful advancements in understanding and potentially treating the disease.
Where this research is happening
-
Winifred Masterson Burke Med Res Inst
White Plains, United States Active
Researchers
- Principal investigator: Hussaini, S. Abid — Winifred Masterson Burke Med Res Inst
- Study coordinator: Hussaini, S. Abid
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.