Investigating how bone marrow cells affect tumor growth and response to radiation therapy
Official title: The Role of Hematopoietic Stem and Progenitor Cells in Solid Tumor Growth and Response to Radiation Therapy
Funded at Oakland University · NIH-10359313 · Data updated 2026-11-12
This study is looking at how certain cells from the bone marrow affect solid tumors and how they help tumors recover after radiation treatment, with the hope of finding new ways to improve cancer care.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oakland University NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 23, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $449,795 |
| NIH project number | 1R15CA254006-01A1 |
| Project ID | NIH-10359313 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with solid tumors, particularly lung cancer, who are undergoing radiation therapy.
✕Less likely to help
Patients with non-solid tumors or those not receiving radiation therapy may not benefit from this research.
What this research studies
This research focuses on understanding the role of bone marrow-derived hematopoietic stem and progenitor cells (HSPCs) in solid tumors, particularly their influence on tumor growth and recovery after radiation therapy. The study aims to explore how these cells are maintained within tumors and their mechanisms of action, which could provide insights into tumor biology. Researchers will employ both laboratory and animal models to manipulate interactions between HSPCs and the tumor environment, assessing how these changes impact tumor behavior. By filling gaps in current knowledge, this research could lead to new therapeutic strategies for cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by targeting the mechanisms that allow tumors to grow and resist radiation therapy.
How similar studies have gone: Other research has shown success in understanding the role of immune cells in tumor biology, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Oakland University
Rochester, United States Active
Researchers
- Principal investigator: Madlambayan, Gerard James — Oakland University
- Study coordinator: Madlambayan, Gerard James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.