Investigating how bone marrow cells affect tumor growth and recovery after treatment
Official title: Purchase of a Benchtop Flow Cytometer
Funded at Oakland University · NIH-11142100 · Data updated 2026-11-12
This study is looking at how certain blood stem cells from the bone marrow move to lung tumors and help them grow, especially after treatment with radiation, to find new ways to fight cancer.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oakland University NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 23, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $71,873 |
| NIH project number | 3R15CA254006-01A1S1 |
| Project ID | NIH-11142100 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with solid tumors, particularly lung cancer, who are undergoing or have undergone radiation therapy.
✕Less likely to help
Patients with tumors that do not involve bone marrow-derived cells or those who are not receiving radiation therapy may not benefit from this research.
What this research studies
This research focuses on understanding the role of bone marrow-derived hematopoietic stem and progenitor cells (HSPCs) in solid tumors, particularly lung cancers. The study aims to explore how these cells migrate to tumors and contribute to their growth and regrowth after radiation therapy. By examining the interactions between HSPCs and the tumor environment, the researchers will use both laboratory and animal models to uncover the mechanisms that allow these cells to thrive in tumors. This could lead to new insights into tumor biology and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for cancer patients by targeting the mechanisms that allow tumors to regrow.
How similar studies have gone: Previous research has shown that targeting tumor-associated immune cells can impact cancer treatment outcomes, suggesting that this approach may also yield valuable insights.
Where this research is happening
-
Oakland University
Rochester, United States Active
Researchers
- Principal investigator: Madlambayan, Gerard James — Oakland University
- Study coordinator: Madlambayan, Gerard James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.